Biosensors and point-of-care diagnostics

In an aging society, improving the quality of life is one of the most important goals of global research efforts. The field of biosensors is a crucial building block for maintaining and improving the quality of life, as it enables fast, precise and mobile analysis of biomarkers, pathogens or pollutants. Fraunhofer IKTS develops electrochemical biosensors that are characterized by their high sensitivity, easy handling and low price compared to other sensor types. A much more cost-effective production would be possible by using roll-to-roll scalable printing technology on inexpensive and flexible substrates such as paper and polymer films. This approach is particularly interesting for aptamer-functionalized biosensors. These are highly selective, robust and offer a high aptamer loading density on the sensor chip.

Innovative approaches are required to develop a specific electrochemical biosensor system. The performance characteristics of the biosensor such as long-term stability, reusability, fast response times and high selectivity towards the target molecule must be investigated and optimized for each specific application. In particular, the sensitive determination of low substance concentrations requires special measures to increase sensor sensitivity, for example by means of nanostructuring or nanofunctionalization of electrode surface.